The Effect Of Metoprolol On The World Health Organization...

METOPROLOL Introduction Metoprolol is a selective ÃŽ ²1 receptor blocker.1 It is used to treat high blood pressure or hypertension, myocardial infarction (MI), heart failure and angina pectoris.2 Metoprolol was first made in 1969 and is on the World Health Organization’s list of essential medicines.3 Metoprolol is available only in its salt form due to its low melting point, such as metoprolol tartrate or metoprolol succinate. Its salt form, metoprolol tartrate was first developed by Novartis and was approved by FDA on August 7, 1978.4 Metoprolol is also available as a generic drug.1 Drug Profile Figure 1. Chemical Structure of Metoprolol IUPAC Name : 1-(isopropylamino)-3-[4-(2-methoxyethyl)phenoxy] propan-2-ol Chemical Formula : C15H25NO3 Molecular Weight : 267.364 g/mol Trade names : Lopressor, Metolar XR, Toprol XL (US) Nature : Free base exists as a white solid, while its tartrate form exists a fine crystalline material.5 Physical properties* : Solubility – Very soluble (water), Freely soluble (methylene chloride, chloroform, alcohol), Slightly soluble (acetone) and Insoluble (ether).6 Melting point - 120 °C or 248 °F.5 *Properties are given, considering the salt form, metoprolol tartrate. Pregnancy category : C (US). Indicates that it’s a risk when used during pregnancy. Route of administration : Oral and Intravenous (IV) Pharmacokinetic data : Bioavailability – 50%7 Protein binding – 12% Metabolism – Liver via CYP2D6, CYP3A4 Half-Life – 3-7 hoursShow MoreRelatedSelf Medication Practices in a Rural Filipino Community21296 Words   |  86 PagesUNIVERSITY OF SAINT LOUIS TUGUEGARAO TUGUEGARAO CITY, CAGAYAN College Of Health and Allied Sciences Master Of Science In Nursing Major In Adult Health Nursing In fulfillment of the Requirement for the Degree Master of Science in Nursing Major in Adult Health Nursing Factors Affecting The Prevalence Of Self Medication Using Commercial Drugs In A Rural Filipino Family For The Course Research II With Statistics Presented by: Elaiza Joy M. Claravall Hazel Faith W. Cortel Read MorePharmaceutical Price Controls in the Oecd Countries47662 Words   |  191 Pages22161; www.ntis.gov. ii U.S. Department of Commerce, International Trade Administration Contents Executive Summary vii 1 Introduction 1 2 Drug Price Regulations in Selected OECD Countries—An Overview of the Issues 3 3 Price And Revenue Effects 10 4 Impact of Deregulating Prices on Research and Development, Innovation, and Consumers 25 Appendix A: Technical Methodology 35 Appendix B: Drug Pricing Study—Federal Register Notice Responses 49 Appendix C: Report on Pharmaceutical Markets in 11Read MoreThe Marketing Research of Brainquiry33782 Words   |  136 Pagestools and how much they would budget for that. The German research gives an overview of a sample of contact details of doctors divided into users and non users of neuro/biofeedback. This information is to be found on the CD in the folder Germany. A list of contact details for golf clubs throughout Germany is given in the same excel file as mentioned before. If more contacts are needed they can be found by using the means stated in the sources part of the research. The excel file gives furthermoreRead MoreComprehensive 1 Essay18452 Words   |  74 Pagestransmitted by the bite of an infected deer tick, and antiviral agents (D) are ineffective. Symptoms, such as fever, chills, headache, stiff neck, fatigue, and swollen lymph nodes are more typical, not nausea and vomiting (C).   Category:   Community Health Awarded 1.0 points out of 1.0 possible points. 2. 2.ID: 310982379 The nurse is planning a wellness program aimed at primary prevention in the community. Which action should the nurse implement? A.   Immunizations that decrease occurrences of many contagious